RUFLOXACIN (MF-934) - INVITRO AND INVIVO ANTIBACTERIAL ACTIVITY

  • 1 January 1989
    • journal article
    • research article
    • Vol. 15  (1) , 11-15
Abstract
Rulfoxacin (MF-934) is a new quinolone which shows in vitro antibacterial activity against Escherichia coli, Salmonella, Klebsiella, Proteus and Staphylococcus spp. Lower in vitro activity was observed with Pseudomonas, Serratia, Enterobacter and the streptococci group D. The antimicrobial activity of MF-934 in vitro is higher than that of nalidixic acid but lower than that of ciprofloxacin, olfloxacin, pefloxacin or norfloxacin. The protective effects of MF-934 in systemic infections in mice are lower than those of ciprofloxacin oand ofloxacin. In respiratory infections in rats and in subcutaneous infections in guinea-pigs, the protective effects of MF-934 are of the same order as ciprofloxacin and ofloxacin. This is probably due to the pharmacokinetic properties of MF-934, i.e. the long half-life and tissue concentrations higher than plasma levels.

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