Studies of the influence of ochratoxin A on immune and defence reactions in the mouse model
- 1 January 1995
- Vol. 38 (1-2) , 85-91
- https://doi.org/10.1111/j.1439-0507.1995.tb00013.x
Abstract
Summary. In the mouse model, the mycotoxin ochratoxin A has a non-selective suppressive effect on various immune and defence reactions. Apart from weight depression, lymphopenia, neutrophilia and eosinophilia, antibody-producing cells, antibody titres in blood serum and phagocytosis of Escherichia coli by blood phagocytes become suppressed. Moreover, immunized animals show a lower survival rate after experimental infection with Pasteurella multocida as well as an increase in oxygen radicals in blood cells. Zusammenfassung. Das Mykotoxin Ochratoxin A wirkt nichtselektiv suppressiv auf verschiedene Immun- und Abwehrvorgänge bei Modellun-tersuchungen an der Maus. Neben Gewichts-depressionen, Lymphopenie, Neutrophilie und einer Eosinophilie kommt es zu Suppressionen Antikörper-bildender Zellen, der Antikörpertiter im Blutserum, der Phagozytose von Escherichia coli durch Blutphagozyten, einer geringeren Überle-bensrate immunisierter Tiere nach experimenteller Infektion mit Pasteurella multocida sowie zu einem Anstieg von Sauerstoffradikalen in Blutzellen.Keywords
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