Deficient resistance toCoccidioides immitisfollowing intravenous vaccination

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Abstract
Intramuscular vaccination with killed spherules induced strong immunity to lethal coccidioidal disease in mice. A wide range of dose and small incremental dosage gave uniformly poor protection when administered intravenously. In imuran- or cortisone-treated leukopenic or lymphopenic mice intravenous vaccination did not result in augmented immunity later, after leukocyte numbers had become normal. In both leukopenic and nonleukopenic intravenously-vaccinated animals the cellular response was primarily neutrophilic. These findings did not support earlier speculation that the deficient immune response in intravenously vaccinated mice was attributable to immune tolerance.

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