Stress-related pain behavior in rats with peripheral nerve injuries

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Abstract
The effects of cold stress were studied on rats with unilaterally sectioned sciatic nerves. Behaviors suggestive of pain occurred in a number of these animals. These behaviors vanished when removing the rats from the stressful environment. Some severely painful syndromes in man [e.g., causalgia and phantom pain syndrome] might in part be due to mechanisms similar to those underlying the described behaviors in rats [i.e., through effects on the sympathetic nervous system].