Modifications of the Nuclear Envelope of BHK Cells After Infection with Herpes Simplex Virus Type 1
- 1 November 1982
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 63 (1) , 81-94
- https://doi.org/10.1099/0022-1317-63-1-81
Abstract
Numerous discrete lesions, which have been termed blebs, appeared in the nucleus of hamster kidney BHK cells 10-15 h after infection with herpes simplex virus type 1 (HSV-1). They were formed in the inner portion of the nuclear envelope by the apposition of 2 thickened lamellae overlying a vacuole. As demonstrated by EM studies, blebs were regular and associated with the peripheral lamina in the nucleus, averaging 3.5 blebs/.mu.2. They appeared to be associated with an enrichment of the 155K major capsid protein in the nuclear membrane subfractions as compared with the protein composition of nuclei and plasma membrane fractions. Evidently, blebs represent the site of assembly of capsid proteins before DNA insertion and eventual envelopment.This publication has 1 reference indexed in Scilit:
- The Replication of HerpesvirusesPublished by Springer Nature ,1974