Stimulation by Interferon of the Differentiation of Human Promyelocytic Leukemia (HL-60) Cells Produced by Retinoic Acid and Actinomycin D

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Abstract
Interferons (IFNs) have been shown to enhance or induce differentiation in several model systems, either alone or in combination with differentiating agents. To further study these phenomena, the effects of the recombinant interferons rlFN-αA, rIFN-αD, rlFN-αA/D (Bgl II), rIFN-β, and rIFN-γ on the differentiation-producing capacities of the anticancer agents aclacinomycin A and actinomycin D, and the differentiating agent retinoic acid, were examined in the HL-60 promyelocytic leukemia cell line. The addition of IFNs to aclacinomycin A did not produce any enhancement of differentiating capacity. The differentiating capacity of actinomycin D was enhanced only by rIFN-αA/D (Bgl II). The differentiating capacity of retinoic acid was enhanced by all the IFNs-α tested, and by rIFN-β, but not rIFN-γ.

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