A new route for the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via oxidation of cyclic secondary amine
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 3,p. 385-386
- https://doi.org/10.1039/cc9960000385
Abstract
The synthesis of the imine-containing pyrrolo[2,1-c][1,4]benzodiazepine DNA–binding antitumour antibiotics was achieved by a new method of oxidation of cyclic secondary amines which does not endanger the stereochemical integrity of the C-11a position.Keywords
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