An investigation of the pore structure of tablets of sucrose and lactose by mercury porosimetry

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Abstract
The pore structure of tablets has been investigated by mercury porosimetry. Tablets, when prepared from ungranulated powder, showed a narrow pore size distribution, the mode of which decreased from 9 to 1 μm over the pressure range studied. Granulation caused the size distribution of tablet pores to widen. Large robust granules, compressed at low pressures, gave tablets with a bimodal pore size distribution. Decrease in granule size and strength, promoted a more uniform tablet structure and fine, friable, granules, compressed at high pressures, gave tablets with almost the same structure as those prepared from ungranulated powder.

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