Regulation of the human β-actin promoter by upstream and intron domains
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (2) , 601-615
- https://doi.org/10.1093/nar/17.2.601
Abstract
We have identified three regulatory domains of the complex human .beta.-actin gene promoter. They span a region of about 3000 bases, from not more than -2011 bases upstream of the mRNA cap site to within the 5'' intron (832 bases long). A distal upstream domain contains at least one enhancer-like element. A proximal upstream domain, with a CArG [for CC(A+T rich)6GG] motif found in all known mammalian actin gene, seems to confer serum, but not growth factor, inducibility. The third domain is within the evolutionarily conserved 3'' region of the first intron and contains a 13 base-pair sequence, identical to the upstream sequence with the CArG motif. This domain also contains sequences that are both serum and fibroblast growth factor inducible.This publication has 38 references indexed in Scilit:
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