Reversal of Chemotaxis in vitro and Chemotactic Activity of Leukocyte Fractions.

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Abstract
Summary Using Boyden'sin vitro method, it was demonstrated that rabbit polymorpho-nuclear leukocytes reversed their direction of migration in response to a concentration gradient of chemotactic serum. The presence of a chemotactic factor or factors associated with the lysosomal fraction of leukocytes which does not require fresh serum for its activity was shown. I am very grateful to Dr. Richard B. Crandall for the use of his laboratory and for his valuable advice, and also to Drs. E. Suter and J. J. Cebra for comments and suggestions.