"GAMMA GLOBULIN" AND "PLACENTAL GLOBULIN"
- 9 December 1944
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 126 (15) , 944-947
- https://doi.org/10.1001/jama.1944.02850500016004
Abstract
Three agents are currently recommended for the prophylaxis of measles—convalescent human serum, placental globulin (immune globulin-human) and gamma globulin derived from normal human serum (human immune serum globulin). Concentrated, pooled ascites fluid1has also been suggested but has not come into general use and will not be discussed here. The prophylactic effectiveness of convalescent serum has been recently summarized in a well controlled study of 502 household contacts between the ages of 6 months and 15 years by Stillerman, Marks and Thalhimer.2These authors obtained complete protection in 50 per cent, modified measles in 49 per cent and regular measles in 1 per cent of the individuals studied. While the effectiveness of convalescent serum is not questioned, its lack of ready availability and the comparatively large doses which are necessary make its use unpractical. This study is directed toward the comparison of the effectiveness and incidence of untowardKeywords
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