Thromboxane B2 biosynthesis and phospholipids hydrolysis in platelets from hypercholesterolemic rabbits
- 1 January 1981
- Vol. 16 (1) , 37-42
- https://doi.org/10.1007/bf02534919
Abstract
Thromboxane B2 biosynthesis from arachidonic acid was increased in platelets from hypercholesterolemic rabbits. The enzymic activity of phospholipase A2 which releases arachidonic acid, the precursor for the biosynthesis of thromboxane B2, showed little change in hypercholesterolemic platelets. Phospholipase C and diglyceride lipase activities were not changed in platelets from hypercholesterolemic rabbits. Phospholipid concentration in platelets was not increased in this state. The supply of precursor for thromboxane B2 biosynthesis was not increased in platelets from hypercholesterolemic rabbits as compared to controls. The enzyme activity of thromboxane B2 biosynthesis may be enhanced in platelets from hypercholesterolemic rabbits.This publication has 29 references indexed in Scilit:
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