Mechanism of Aerobic Decomposition of Angeli's Salt (Sodium Trioxodinitrate) at Physiological pH
- 15 December 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (2) , 722-731
- https://doi.org/10.1021/ja045480z
Abstract
The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.Keywords
This publication has 50 references indexed in Scilit:
- An ab initio molecular orbital study of the potential energy surface of the HO2+NO reactionThe Journal of Chemical Physics, 1997
- Conversion of Nitroxyl (HNO) to Nitric Oxide (NO) in Biological Systems: The Role of Physiological Oxidants and Relevance to the Biological Activity of HNOBiochemical and Biophysical Research Communications, 1993
- Oxidation of dithiothreitol during turnover of nitric oxide reductase: evidence for generation of nitroxyl with the enzyme from Paracoccus denitrificansBiochemical and Biophysical Research Communications, 1992
- Free energy dependence of the rate of long-range electron transfer in proteins. Reorganization energy in ruthenium-modified myoglobinJournal of the American Chemical Society, 1988
- Thermal decomposition of oxyhyponitrite (sodium trioxodinitrate(II)) in aqueous solutionInorganic Chemistry, 1975
- Oxidative determination of α-hyponitratc with alkaline hexacyanoferrate(III)Analytica Chimica Acta, 1974
- Crystal and molecular structure of 5,6-.mu.-diphenylphosphino-decaborane(14)Inorganic Chemistry, 1973
- On the Role of the Nitroxyl Molecule in the Reaction of Hydrogen Atoms with Nitric OxideJournal of the American Chemical Society, 1965
- The formation of peroxynitrite by oxidation of chloramine, hydroxylamine and nitrohydroxamateJournal of Inorganic and Nuclear Chemistry, 1964
- Chlorination of Aromatic Compounds by Antimony Pentachloride1,2Journal of the American Chemical Society, 1960