Distribution of Polymorphic HLA‐DR and ‐DQ Alleles as Determined by Restriction Fragment Length Polymorphism Analysis in an Austrian Population
- 1 May 1992
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 62 (4) , 236-241
- https://doi.org/10.1111/j.1423-0410.1992.tb01205.x
Abstract
The restriction fragment length polymorphism (RFLP) of HLA‐DR β, ‐DQ α and ‐DQ β genes was analyzed in 637 unrelated individuals from the Austrian population. The restriction enzyme was Taq I, and three exon‐specific probes were applied. The gene frequencies, the Hardy‐Weinberg equilibrium in DR β and DQ loci, linkage disequilibria between the loci and haplotype frequencies are calculated. Rare associations between DR and DQ loci are described. Two RFLP patterns are demonstrated which were unique in the overall 1,000 individuals tested so far.Keywords
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