Cu(OBt)2 and Cu(OAt)2, copper(II)‐based racemization suppressors ready for use in fully automated solid‐phase peptide synthesis
- 1 March 2001
- journal article
- Published by Wiley in Journal of Peptide Science
- Vol. 7 (3) , 115-120
- https://doi.org/10.1002/psc.299
Abstract
The complexes Cu(OBt)2 and Cu(OAt)2, which are derived from copper(II) and HOBt and HOAt, respectively, are shown to be more effective in suppressing racemization during solid‐phase peptide synthesis (SPPS) than are those compounds currently being used for this purpose. These compounds can readily be used in conjunction with the commonly applied coupling reagents in fully automated systems for solid‐phase peptide chemistry. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.Keywords
This publication has 7 references indexed in Scilit:
- Nsc and FmocNα-amino protection for solid-phase peptide synthesis: a parallel studyChemical Biology & Drug Design, 2000
- Solid-Phase Peptide Synthesis in the Reverse (N → C) DirectionOrganic Letters, 2000
- Solid-Phase SynthesisPublished by Taylor & Francis ,2000
- Racemization studies of Fmoc-Ser(tBu)-OH during stepwise continuous-flow solid-phase peptide synthesisTetrahedron Letters, 1998
- Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis1,2The Journal of Organic Chemistry, 1997
- Redox‐active bis‐cysteinyl peptides. I. Synthesis of cyclic cystinyl peptides by conventional methods in solution and on solid supportsBiopolymers, 1994
- Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagentsTetrahedron Letters, 1994