Predictors of New-Onset Kidney Disease in a Community-Based Population

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Abstract
Hypertension and diabetes are the leading causes of end-stage renal disease (ESRD).1 Among individuals who develop ESRD, the risk of cardiovascular disease is 10 to 20 times higher than the general population,2-4 and increased risks are evident even in mild kidney disease.5-7 There are approximately 275 000 patients with ESRD in the United States1 and it is estimated that an additional 8 million US adults have kidney disease (defined as a glomerular filtration rate [GFR] of 2).8 Because kidney disease often progresses to ESRD9 and its attendant complications, the identification of precursors of kidney disease is important, with the belief that interventions will prevent or delay the progression to ESRD.