Double-Stranded Regions in Heterogeneous Nuclear RNA from Hela Cells
- 1 September 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (9) , 2537-2541
- https://doi.org/10.1073/pnas.69.9.2537
Abstract
Heterogeneous nuclear RNA from HeLa cells contains double-stranded regions that arise by base pairing of complementary sequences that exist as parts of the same molecule (intramolecular base pairing). When denatured, the RNA sequences that form the double-stranded regions hybridize rapidly to HeLa cell DNA, suggesting that they are transcribed from reiterated sites in the genome. The messenger RNA does not contain the same class or amount of double-stranded RNA regions found in heterogeneous nuclear RNA.Keywords
This publication has 23 references indexed in Scilit:
- Characteristics of the polyadenylic acid segment associated with messenger ribonucleic acid in mouse sarcoma 180 ascites cellsBiochemistry, 1972
- Addition of Polyadenylate Sequences to Virus-Specific RNA during Adenovirus ReplicationProceedings of the National Academy of Sciences, 1971
- Polyadenylic Acid Sequences: Role in Conversion of Nuclear RNA into Messenger RNAScience, 1971
- Polyadenylic Acid Sequences in the Heterogeneous Nuclear RNA and Rapidly-Labeled Polyribosomal RNA of HeLa Cells: Possible Evidence for a Precursor RelationshipProceedings of the National Academy of Sciences, 1971
- An Adenylic Acid-Rich Sequence in Messenger RNA of HeLa Cells and Its Possible Relationship to Reiterated Sites in DNAProceedings of the National Academy of Sciences, 1971
- Homology of Double Stranded RNA from Rat Liver Cells with the Cellular GenomeNature New Biology, 1971
- Fractionation of heterogeneous nuclear RNA: Rates of hybridization and chrosomal distribution of reiterated sequencesJournal of Molecular Biology, 1970
- The distribution of rapidly hybridizing RNA sequences in heterogeneous nuclear RNA and mRNA from hela cellsJournal of Cellular Physiology, 1970
- DEMONSTRATION OF AN UNSTABLE RNA AND OF A PRECURSOR TO RIBOSOMAL RNA IN HELA CELLSProceedings of the National Academy of Sciences, 1963
- Amino Acid Metabolism in Mammalian Cell CulturesScience, 1959