Function of lanGT3, a Glycosyltransferase Gene Involved in Landomycin A Biosynthesis
- 29 October 2004
- journal article
- research article
- Published by Wiley in ChemBioChem
- Vol. 5 (11) , 1567-1570
- https://doi.org/10.1002/cbic.200400123
Abstract
The glycosyltransferase gene lanGT3, involved in the biosynthesis of the angucyclic antibiotic landomycin A, has been characterised by targeted gene deletion. A lanGT3 mutant was shown to produce landomycin E, which consists of a trisaccharide side chain attached to the polyketide moiety. Expression of lanGT3 in the mutant restored landomycin A production. Our results indicate that LanGT3 is responsible for the transfer of the fourth sugar during landomycin A biosynthesis.Keywords
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