Development of new methodologies for the mass spectrometry study of bioorganic macromolecules
- 29 September 2003
- journal article
- review article
- Published by Wiley in Mass Spectrometry Reviews
- Vol. 22 (6) , 369-406
- https://doi.org/10.1002/mas.10062
Abstract
In recent years, mass spectrometry has been increasingly used for the analysis of various macromolecules of biological, biomedical, and biochemical interest. This increase has been made possible by two key developments: the advent of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) sources. The two new techniques produce a significant increase in mass range and in sensitivity that led to the development of new applications and of new analyzer designs, software, and robotics. This review, apart from the description of the status of mass spectrometry in the analysis of bioorganic macromolecules, is mainly devoted to the illustration of the more recent promising techniques and on their possible future evolution.Keywords
This publication has 101 references indexed in Scilit:
- A new technique for unbiased external ion accumulation in a quadrupole two‐dimensional ion trap for electrospray ionization Fourier transform ion cyclotron resonance mass spectrometryRapid Communications in Mass Spectrometry, 2001
- Evaluation of axial DC offsets during scanning of a quadrupole ion trap for sensitivity improvementsRapid Communications in Mass Spectrometry, 2001
- Investigation of the quantitative properties of the quadrupole orthogonal acceleration time-of-flight mass spectrometer with electrospray ionisation using 3,4-methylenedioxymethamphetamineRapid Communications in Mass Spectrometry, 1999
- Mass spectrometric analysis of lipo-chitin oligosaccharides-Signal molecules mediating the host-specific legume-rhizobium symbiosisMass Spectrometry Reviews, 1998
- Ion/ion chemistry of high-mass multiply charged ionsMass Spectrometry Reviews, 1998
- An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein databaseJournal of the American Society for Mass Spectrometry, 1994
- Laser assisted reflectron time-of-flight mass spectrometryInternational Journal of Mass Spectrometry and Ion Processes, 1994
- Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltonsAnalytical Chemistry, 1988
- Quantitative behavior of surfactants at the liquid/vacuum interface by secondary ion mass spectrometryInternational Journal of Mass Spectrometry and Ion Processes, 1984
- Fast atom bombardment: A new mass spectrometric method for peptide sequence analysisBiochemical and Biophysical Research Communications, 1981