Excretion of Zinc in Rat Bile - A Role of Glutathione

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Abstract
Fractionation of the bile from rats injected with 65ZnCl2 (5 .mu.mol/kg) showed that Zn was mainly bound to low MW compounds eluted corresponding to the Zn-glutathione complexes. Diethylmaleate (3.9 mmol/kg), cyclohexene oxide (4.9 mmol/kg) and acrylamide (3.5 mmol/kg) administered i.p. to rats caused a rapid decrease in the endogenous excretion of Zn and reduced glutathione into bile. This depression probably reflected the conjugation of these substances to glutathione in the liver cells. Zn was transferred from liver to bile by a glutathione-dependent process and most likely as Zn-glutathione complexes.

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