Acute and chronic graft-versus-host disease
- 1 March 1993
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Oncology
- Vol. 5 (2) , 276-281
- https://doi.org/10.1097/00001622-199303000-00005
Abstract
Acute graft-versus-host disease is a two-step process. First, allorecognition of histocompatibility antigen activates T lymphocytes, which releases several cytokines, including interleukin-1 and tumor necrosis factor. Understanding of this activity resulted in new therapeutic approaches. Chronic graft-versus-host disease remains a very frequent and difficult problem to treat. Thalidomide was introduced as therapy for chronic graft-versus-host disease. Although basic research reported this year had no common theme, progress was made in many areas.Keywords
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