Effects of Endotoxin on Myocardial Hemodynamics, Performance, and Metabolism During Beta Adrenergic Blockade

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Abstract
The question of the precise role of the heart in shock has been largely unresolved. Previous separate reports have shown that both excitatory and depressant actions on the myocardium after endotoxin are observed. The purpose of the present study was to assay the possibility of a direct myocardial toxic action of endotoxin or a circulating myocardial depressant factor released in the blood of endotoxin shocked animals. This was accomplished by utilization of beta adrenergic blockade (propranolol) under the experimental conditions of constant cardiac output and aortic pressure in an isolated canine heart preparation exchanging blood with an intact support animal shocked by endotoxin.

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