Adherence of Acinetobacter calcoaceticus RAG-1 to human epithelial cells and to hexadecane

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Abstract
The ability of A. calcoaceticus RAG-1 to adhere to human epithelial cells was investigated and compared with its ability to adhere to a test hydrocarbon (hexadecane). RAG-1, a microorganism originally isolated for growth on hydrocarbon, adhered to epithelial cells when grown under conditions which promote its adherence to hexadecane; RAG-1 cells adhered poorly to epithelial cells when grown under conditions which cause the cells to possess low affinity towards hexadecane. A mutant derived from RAG-1, MR-481, deficient in its ability to adhere to hydrocarbon, was similary unable to adhere to epithelial cells. RAG-1 adherence to epithelial cells was not blocked by a number of sugars tested. Streptococcus pyogenes, whose adherence to epithelial cells was previously attributed to hydrophobic interactions, was also able to adhere to hexadecane. Hydrophobic interactions apparently mediate adherence of the strains studied to both epithelial cells and hydrocarbon.