Mechanical properties of bone cements containing large doses of antibiotic powders
- 1 November 1976
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 10 (6) , 929-938
- https://doi.org/10.1002/jbm.820100610
Abstract
The addition of up to 10 g gentamicin sulfate antibiotic powder to 60 g units of Simplex-P acrylic bone cement caused gradual, proportional decreases in the bulk mechanical properties of compressive and diametral tensile stengths. Water leaching of the antibiotic from the cement did not significantly decrease these strengths. Scanning electron microscopy (SEM) and energy-dispersive x-ray spectroscopy (EDS) showed the antibiotic to reside in the acrylic matrix as discrete particles not usually associated with internal porosity. The surface-sensitive flexural strength of a proprietary bone cement was lowered immediately by small quantities of antibiotic powder, and continued to decrease as doses of up to 10 g/unit were admixed. Water leaching caused channeling as the antibiotic was removed from the surface, but it did not create further changes in flexural strength.This publication has 3 references indexed in Scilit:
- Degree of polymerization of acrylic bone cementJournal of Biomedical Materials Research, 1975
- On the Stability of the Mechanical Properties of Self-Curing Acrylic Bone CementJournal of Bone and Joint Surgery, 1974
- Über die Freisetzung von Gentamycin aus Polymethylmethacrylat I. Experimentelle Untersuchungenin vitroLangenbecks Archives Of Surgery, 1972