ARTHRITIS AND INTESTINAL DISEASES: A COMPARISON OF TWO FAMILY STUDIES

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Abstract
A comparison has been made between the results of two family studies. Ninety-one patients with ulcerative colitis, 116 patients with Crohn's disease and 449 of their relatives and spouses were examined clinically and radiologically. A further 96 relatives and spouses were reviewed radiologically only. Intestinal synovitis was found more frequently in patients with Crohn's disease than in those with ulcerative colitis. This result was in accord with published evidence and theoretical considerations. Sacro-iliitis was found in similar proportions of probands, first-degree relatives, second-degree relatives, and spouses in each study. More of the subjects in the ulcerative colitis study were diagnosed as having ankylosing spondylitis, while a greater proportion of subjects with sacro-illtis in the Crohn's disease study were female. The possible interrelationship between these facts has been discussed.

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