Selective inhibition of NF‐κB activation by the flavonoid hepatoprotector silymarin in HepG2
- 27 November 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 440 (1-2) , 8-12
- https://doi.org/10.1016/s0014-5793(98)01409-4
Abstract
The bioflavonoid silymarin is found to potently suppress both nuclear factor kappa-B (NF-κB)-DNA binding activity and its dependent gene expression induced by okadaic acid in the hepatoma cell line HepG2. Surprisingly, tumor necrosis factor-α-induced NF-κB activation was not affected by silymarin, thus demonstrating a pathway-dependent inhibition by silymarin. Many genes encoding the proteins of the hepatic acute phase response are under the control of the transcription factor NF-κB, a key regulator in the inflammatory and immune reactions. Thus, the inhibitory effect of silymarin on NF-κB activation could be involved in its hepatoprotective property.Keywords
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