Cytoskeleton cross‐talk during cell motility

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Abstract
Cell crawling entails the co‐ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of the microtubule cytoskeleton. By exerting relaxing effects on substrate contact assemblies in a site‐ and dose‐specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity.