Platelet‐activating factor stimulates a Fos/Jun/AP‐1 transcriptional signaling system in human neuroblastoma cells
- 1 December 1989
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 24 (4) , 558-566
- https://doi.org/10.1002/jnr.490240414
Abstract
Platelet‐activating factor (PAF) elicits a rapid and transient activation of the proto‐oncogenes c‐fos and c‐jun in SH‐SY5Y neuroblastoma cells, but only to a minor extent in Molt‐4 T‐lymphocytes. This effect is inhibited by pretreatment of cells with the PAF antagonist BN 52021, suggesting the involvement of a specific receptor. Moreover, PAF treatment can activate gene expression through an AP‐1 element, and we propose that genomic trans‐activation may occur in target genes containing a functional AP‐1 transcription sequence. These results may further under standing of the molecular mechanisms by which PAF contributes to long‐term phenotypic changes in the nervous system.Keywords
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