The Effect of the Oral Administration of Pancreatin on Fecal Nitrogen and Fat Loss in Achylia Pancreatica

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Abstract
The pancreatic juice was completely excluded from the intestine in seven dogs. For a period of a month or more the animals were maintained in excellent condition on a mixed diet and raw pancreas. Five dogs were then placed on a submaintenance diet of 200 gm. lean beef for three consecutive 7-day periods (21 days). Pancreatin (25 gm.; potency two times U.S.P.) was given during the second 7-day period. This procedure was repeated with four dogs on a maintenance diet of 600 gm. of trimmed beef heart. Analysis of the feces for nitrogen and fat showed that pancreatin decreased the elimination of these constitutents about 60% and 59%, respectively, regardless of the quantity of diet fed. Fecal bulk was reduced 37 to 42%, and the stools became better formed and drier. It is concluded that potent pancreatin, when given in the form of enteric coated tablets and in adequate amount is significantly effective in reducing nitrogen and fat loss in the feces of dogs having achylia pancreatica.