INTRAMUSCULAR PRESSURE CHANGES IN SHOCK

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Abstract
Henderson''s method was utilized for studying changes in intramuscular pressure (IMP) under the following experimental conditions: (a) pentobarbital Na anethesia of long and short duration; (b) before and after intraven. injn. of adrenalin; (c) following morphine plus pentobarbital Na anesthesia; (d) fatal shock induced by 4 different procedures; and (e) sublethal hemorrhage without shock. Pentobarbital Na anesthesia of 12 hrs.'' duration did not induce any greater change in IMP than anesthesia lasting 2-3 hrs. Adrenalin, administered by vein, raised both the blood pressure and IMP, but the latter remained elevated long after the blood pressure had returned to normal. Morphine, followed by intraven. administered pentobarbital Na, lowered both the arterial pressure and IMP for several hrs. Shock induced in deeply anesthetized dogs by release of limb tourniquets, application of a limb press, trauma to muscle masses of the hind legs, and gun shot injury, was accompanied in all cases by marked fall in the IMP. Sub-lethal hemorrhage, without shock representing 33 ml./kg. of body wt., caused a sharp rise in IMP which was maintained for several hrs. after spontaneous return of the blood pressure to normal. Reinfusion of heparinized whole blood in the hemorrhaged dogs resulted in decline of the IMP to control levels.

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