OBSERVATIONS ON GROWTH (CHONDROTROPHIC) HORMONE AND LOCALIZATION OF ITS POINT OF ATTACK

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Abstract
Acromegaly, dwarfism, and gigantism are generally attributed to pituitary dysfunction. Hypophysectomy is followed by dwarfism, while treatment with alkaline extracts of the pituitary leads to gigantism according to Evans and Long [1921]. Putnam, Benedict, and Teel [1929] found symptoms of acromegaly in dogs after similar treatment, and their findings were confirmed by Evans [1935]. The problem of growth, in spite of these fundamental facts, is far from being solved. Clinical results with growth hormone preparations are disappointing or at least uncertain, and even the experimental gigantism in rats has not been reproduced by others since 1921. Some authorities in this field of research question even the very existence of growth hormone, and Riddle and Bates [1933, 1935, 1938] suggest that certain pituitary extracts owe their action upon growth to 'a balanced combination' of prolactin, thyreo-, or perhaps adrenotropic hormones rather than to a special growth hormone. Reiss [1937] pointed out

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