Inhibitory Effect of Glycyrrhizin and Caffeine on Two-stage Carcinogenesis in Mice

Abstract
Glycyrrhizin and caffeine inhibited the action of tumor promoter in mouse skin correspondingly to the effect of quercetin. Glycyrrhizin and caffeine inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, and these markedly suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.