Histamine stimulates renin release from the isolated perfused rat kidney

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Abstract
Summary The renal effects of histamine, histamine receptor agonists and antagonists were studied in the isolated rat kidney, which was perfused with a synthetic medium at constant perfusion pressure in a single pass system. Histamine induced a concentration-dependent increase of renin release ranging from a two-fold increase at 0.5 μM to a four-fold increase at 10 μM. No change in renal vascular resistance, glomerular filtration rate and sodium excretion occurred. Histamine-H2-antagonists (ranitidine and cimetidine) were more effective to block the response to histamine than was the histamine H1-antagonist diphenhydramine. Histamine-H2-agonists (impromidine and dimaprit, 2.5 μM each) were potent stimulators of renin release, their effect was blunted by H2-antagonists. The histamine-H1-agonist pyridyl-2-ethylamine had a low stimulatory activity at 10 μM final concentration, which may reflect partial H2-agonistic effects. It is concluded that histamine stimulates renin release via H2-receptor activation.