THE RELATIVE ESTROGENIC ACTIVITY OF COMPOUNDS RELATED TO ESTRIOL1,2

Publisher Website
Google Scholar
Abstract
THE EXISTENCE of a reversible equilibrium between estrone and α-estradiol and the conversion of the former to the latter in the human being is well established. The pathway of the conversion of estrone to estriol is still, however, a matter of speculation. A knowledge of the exact course of estrogen metabolism is important for it may lead to the production of more active naturally occurring estrogens as well as to better concepts of the possible role of these compounds in carcinogenesis and in the body economy in general (Grollman, 1947). We have determined the estrogenic activities of various compounds, prepared by partial synthesis from estrone, which may conceivably fall along the normal or abnormal course of estrone metabolism. The results permit certain speculations regarding the pathway for the transformation of estrone to estirol. MATERIALS AND METHODS The following compounds have been used in the present study: estradiol, estriol, estrone, “Ruzicka’s triol,” 16-keto-α-estradiol, isoestriol-A (Huffman 3 and Darby, 1944), and 16-ketoestrone.

This publication has 4 references indexed in Scilit: