XYLAZINE-INDUCED HYPERGLYCEMIA IN BEEF-CATTLE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (1) , 127-129
Abstract
I.v. administration of xylazine to beef cattle (10 animals, 0.2 mg/kg of body weight) resulted in rapid onset (< 15 min) of hyperglycemia. Plasma glucose values increased to 195 .+-. 15 mg/dl and 305 .+-. 10 mg/dl at 15 min and 3 h, respectively. Concomitantly, plasma insulin concentrations dropped from 23 .+-. 2 .mu.U[microunits]/ml before xylazine to 5.8 .+-. 0.7 .mu.U/ml and 2.4 .+-. 0.3 .mu.U/ml at 15 min and 3 h, respectively. Parallel decreases (20%) were observed for percentage of Hb, red blood cell number and packed cell volume. Plasma urea N was significantly (P > 0.01) increased within 3 h of xylazine administration (6.7 .+-. 0.9 mg/dl vs. 11.4 .+-. 0.7 mg/dl). Marked changes in concentrations of plasma-free fatty acids were not observed. Alternative means of anesthesia must be considered in those instances in which biopsy material is used for studies of carbohydrate metabolism in vitro.

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