Common Genomic Variants Associated With Variation in Plasma Lipoproteins in Young Aboriginal Canadians

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Abstract
We hypothesized that common genomic variants would be associated with variation in lipoprotein phenotypes in young subjects. We determined genotypes of FABP2 , PON , APOC3 , and APOE in 188 aboriginal Canadians, aged 9 to 17 years. We found that 13 of 32 possible genotype-phenotype associations were significant: (1) the FABP2 codon 54 genotype was associated with variation in plasma triglycerides ( P =.045); (2) the PON codon 192 genotype was associated with variation in plasma total and LDL cholesterol and apoB ( P =.0099, P =.0088, and P =.016, respectively); (3) the APOC3 insulin-response-element genotype was associated with variation in plasma triglycerides, HDL cholesterol, apoA-I, the total cholesterol to HDL cholesterol ratio, and the apoB to apoA-I ratio ( P =.0014, P =.0069, P =.045, P =.0021, and P =.0081, respectively); and (4) the APOE restriction isotype was associated with variation in plasma LDL cholesterol, apoB, the total cholesterol to HDL cholesterol ratio, and the apoB to apoA-I ratio ( P =.025, P =.034, P =.045, and P =.047, respectively). The average young age and relative absence of age-dependent secondary environmental factors could have eased the identification of small genetic effects on lipoprotein phenotypes in this study sample.