Secretory phospholipase A2 activity correlates with postinjury multiple organ failure

Publisher Website
Google Scholar
Abstract
Postinjury multiple organ failure (MOF) may result from overwhelming systemic hyperinflammation. Secretory phospholipase A2 (sPLA2) produces many inflammatory lipid mediators, and levels have been correlated with both the severity of patient injury and postinjury mortality. The objective of this study was to characterize the plasma activity of sPLA2 type IIa in severely injured patients and to determine whether the activity of this enzyme correlates with the subsequent development of MOF. Seventeen severely injured patients at known risk for MOF had blood sampled on postinjury days 0, 1, 2, 3, and 5. sPLA2 activity was sequentially measured and correlated with MOF scores. Six patients (35%) developed MOF. In comparison with non-MOF patients, MOF patients had elevated sPLA2 activity beginning 36 hrs postinjury (MOF sPLA2, 2.4 ± 0.97, vs. non-MOF sPLA2, 0.86 ± 0.16 active units (AU);p 2 We conclude that increased sPLA2 activity is associated with the development of postinjury MOF.