Cowden's Disease Associated With Immunodeficiency
- 1 September 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 117 (9) , 573-575
- https://doi.org/10.1001/archderm.1981.01650090055027
Abstract
• Cowden's disease is an autosomal dominant disease characterized by verrucous lesions, mucosal papules, and trichilemmomas associated with gastrointestinal tract, thyroid, CNS, and musculoskeletal abnormalities. In addition, our patient exhibited a deficiency of T-lymphocyte function, with recurrent cellulitis and abscess formation, and the eventual development of acute myelogenous leukemia. The defect in T-lymphocyte function may help to explain the higher incidence of malignant neoplasms in patients with Cowden's disease. We recommend complete immunologic examination of patients with this disorder. (Arch Dermatol 1981;117:573-575)This publication has 2 references indexed in Scilit:
- Trichilemmoma. Analysis of 40 new casesArchives of Dermatology, 1973
- Skin, heredity, and cancerCancer, 1969