Fertility in a Man With Cystic Fibrosis

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Abstract
CYSTIC fibrosis generally has been considered a childhood disease, although many patients now reach adulthood.1 In addition to other medical problems such as pulmonary and pancreatic insufficiency, male patients are usually infertile because of maldevelopment of mesonephric ducts or mesonephric obstruction and atresia.2,3 A small number of fertile patients with relatively late-appearing and somewhat milder disease has been identified recently. Feigelson et al4 and Taussig et al5 first reported fertility in men with cystic fibrosis, all of whom had late-appearing disease manifestations, particularly pulmonary symptoms. Our patient had well-compensated and late-appearing cystic fibrosis manifested by moderately decreased exercise tolerance and a normal semen analysis, and he had presumably fathered one child. Report of a Case A 30-year-old man was seen for complaints of intermittent diarrhea since 1970 and frequent respiratory infections since 1972. Despite severe, productive, early-morning cough since his late teens, he was able to

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