Effects of α-amanitin on the stimulation of prostatic ribonucleic acid polymerase by prostatic steroid–protein receptor complexes
- 1 June 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 140 (3) , 565-567
- https://doi.org/10.1042/bj1400565
Abstract
Stimulation of prostatic RNA polymerase in vitro by prostatic 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)–receptor complexes has been previously reported. By use of the selective inhibitor, α-amanitin, we have shown that both nucleolar and extranucleolar RNA polymerase activities may be stimulated, but stimulation is abolished at high ionic strength.Keywords
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