COAGULATION AND FIBRINOLYTIC STUDIES DURING CONTINUOUS USE OF LOW DOSE GESTAGEN

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Abstract
Coagulation factors and the fibrinolytic system were studied in 28 apparently healthy women using low dose gestagen continuously as a contraceptive (0.5 mg chlormadinone acetate daily). The fibrinolytic activity in the blood was also assessed after venous stasis. In 10 of the women determinations were also made of the content of activators of fibrinolysis in the walls of the veins by means of Todd's histochemical method. In contrast to what is seen after the use of contraceptive preparations of combined or sequential type, no changes were found in the factors studied. The increase in the fibrinolytic activity normally produced by venous stasis was not inhibited. The content of activators of fibrinolysis in the walls of the veins was unchanged.

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