FOUR RECENT INFLUENZA EPIDEMICS: AN EXPERIMENTAL STUDY

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Abstract
Epidemic influenza virus was isolated from cases of influenza in 4 epidemics during 1939 (but was not isolated from various cases of acute respiratory disease which occurred prior to the epidemics). The strains isolated produced inconstant reactions in ferrets, and the exptl. disease was typically mild. The strains were not easily adapted in mice. The neutralizing antibody titer increased rapidly after the 5th day of disease and reached maximum levels between the 10th and 14th days. Contacts developed a significant increase in neutralizing antibody titer without manifesting any symptoms. No increase in neutralizing antibody titer occurred during convalescence from 4 different noninfluenzal respiratory infections.

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