Intramolecular Aglycon Delivery (IAD): The Solution to 1,2-cisStereocontrol for Oligosaccharide Synthesis?
- 8 October 2003
- journal article
- account
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2003 (13) , 1945-1958
- https://doi.org/10.1055/s-2003-42056
Abstract
Intramolecular glycosylation of a glycosyl acceptor temporarily tethered to the 2-hydroxyl group of the glycosyl donor, commonly referred to as Intramolecular Aglycon Delivery (IAD), potentially provides a solution to the perennial problem of how to synthesise 1,2-cis glycosidic linkages with complete stereocontrol. This account summarises developments in this area, focussing on the development within our group of intramolecular glycosylation based on allyl protecting groups (allyl IAD). Optimisation, the current scope and limitations, and further potential developments of allyl IAD are discussed herein.Keywords
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