PHARMACOKINETIC PROPERTIES OF CARPROFEN IN HUMANS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 5  (4) , 492-502
Abstract
The pharmacokinetics of carprofen [an antiinflammatory drug] in healthy subjects is described. Carprofen is rapidly and completely absorbed. The maximum concentration in plasma is reached after 1 h and the absolute bioavailability of the oral forms reaches values of over 90%. The elimination half-life is 10 h. The multiple-dose kinetics could be predicted adequately, using pharmacokinetic parameters of the single-dose kinetics. A clear accumulation of carprofen in plasma was not observed. In clinical-therapeutic use the kinetics are not significantly influenced by food intake or by age.

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