STEROID BIOSYNTHESIS. RELATIVE EFFICIENCIES OF ENZYMIC TRANSFORMATION OF TERMINALLY MODIFIED SQUALENE 2,3-OXIDE ANALOGS INTO LANOSTEROL ANALOGS BY 2,3-OXIDOSQUALENE CYCLASE
- 5 December 1973
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 2 (12) , 1289-1292
- https://doi.org/10.1246/cl.1973.1289
Abstract
The incubation of terminally modified squalene 2,3-oxide analogs with the enzyme preparation of hog liver yielded the corresponding lanosterol analogs, respectively, at different conversion rates. The interaction of 2,3-oxidosqualene cyclase with the substrates has thus been found to be influenced by the bulk of the terminal moiety.Keywords
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