Pentaketide metabolites of melanin synthesis in the dematiaceous fungus Wangiella dermatitidis
- 1 April 1984
- journal article
- research article
- Published by Springer Nature in Archiv für Mikrobiologie
- Vol. 137 (4) , 324-328
- https://doi.org/10.1007/bf00410729
Abstract
Melanin synthesis in the dematiaceous, polymorphic hyphomycete Wangiella dermatitidis, a human pathogen, was investigated by biochemical and physiological techniques. Mutants with a decrease or loss in melanin synthesis were induced and isolated. Melanin precursors were obtained from the mutants, purified, and then identified by comparison with authentic compounds from Verticillium dahliae. Isolation of scytalone, vermelone, flaviolin, and 1,8-dihydroxynaphthalene from the mutants of Wangiella dermatitidis, and cross-feeding of the mutants with those of Verticillium dahliae indicated that melanin synthesis in this organism took place by the pentaketide pathway. Melanin that formed in cell walls of an albino mutant treated with scytalone was identical in appearance to that in cell walls of the wild-type strain. This also suggested that pentaketide synthesis of melanin occurred in the fungus.Keywords
This publication has 32 references indexed in Scilit:
- Comparisons of fungal melanin biosynthesis in ascomycetous, imperfect and basidiomycetous fungiTransactions of the British Mycological Society, 1983
- Action of the antipenetrant, tricyclazole, on appressoria of Pyricularia oryzaePhysiological Plant Pathology, 1983
- Melanin biosynthesis inVerticillium dahliae: Dehydration and reduction reactions in cell-free homogenatesExperimental Mycology, 1982
- The Effect of Non-fungicidal Anti-blast Chemicals on the Melanin Biosynthesis and Infection by Pyricularia oryzaeJournal of Pesticide Science, 1982
- The selective inhibition of ortho- and para-diphenol oxidasesPhytochemistry, 1980
- Melanin biosynthesis in Thielaviopsis basicolaExperimental Mycology, 1979
- Ultrastructural and chemical distinction of melanins formed by Verticillium dahliae from (+)-scytalone, 1,8-dihydroxynaphthalene, catechol, and L-3,4-dihydroxyphenylalanineCanadian Journal of Microbiology, 1978
- Pentaketide metabolites of Verticillium dahliae. 3. Identification of (-)-3,4-dihydro-3,8-dihydroxy-1(2H)naphthalenone[(-)-vermelone] as a precursor to melaninThe Journal of Organic Chemistry, 1976
- Use of mutants to establish (+)-scytalone as an intermediate in melanin biosynthesis by Verticillium dahliaeCanadian Journal of Microbiology, 1976
- Nuclear magnetic resonance studies of hydrogen bonding and aromatic proton shifts in substituted naphthalenesSpectrochimica Acta, 1963