Reactions of Oxaprozin-1-0-Acyl Glucuronide in Solutions of Human Plasma and Albumin
- 1 January 1986
- book chapter
- Published by Springer Nature
- Vol. 197, 431-441
- https://doi.org/10.1007/978-1-4684-5134-4_42
Abstract
Acyl glucuronides are major metabolites of many carboxylic acids including drugs, various chemicals, as well as endogenously formed compounds such as bilirubin and benzoic acid. Because of their susceptibility to nucleophilic attack acyl glucuronides are generally less stable than other glucuronides (1). Two reactions, hydrolysis and rearrangement (isomerization by acyl migration), contribute to this instability. Both reactions can occur at physiologic pH values. The extent to which they occur depends on the reactivity of the acyl glucuronide which in turn depends on the structure of its aglycone (2,3).Keywords
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