ATTEMPTS AT DEMONSTRATION OF LIPOPOLYSACCHARIDE IN PHASE-II COXIELLA-BURNETII

  • 1 January 1978
    • journal article
    • research article
    • Vol. 22  (6) , 509-511
Abstract
Comparison of some properties of phase I and phase II C. burnetii cells suggests the presence of lipopolysaccharide (LPS) in the surface structures of phase II cells. Polysaccharide chains were released from them by mild acid hydrolysis and corpuscular residues resulting from such hydrolysis elicited anti-lipid A antibodies in rabbits. Toxicity for adrenalectomized and actinomycin D-sensitized mice was demonstrated with phase I cells, but not with much higher concentrations of phase II cells. The extent of protection against formation of ascitic tumor in mice with comparable concentrations of phase I and phase II cells was similar.