Pyridonecarboxylic acids as antibacterial agents. XII. Synthesis and antibacterial activity of enoxacin analogues with a variant at position 1.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (3) , 1223-1228
- https://doi.org/10.1248/cpb.36.1223
Abstract
Synthesis and antibacterial activity of enoxacin analogues [1-substituted 6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acids] were studied. Alkyl, hydroxyalkyl, chloroalkyl, aralkyl and alkenyl groups were selected as substituents at position 1. Among the compounds prepared in this work, the 1-(2-chloroethyl) analogue is the most active.This publication has 3 references indexed in Scilit:
- Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agentsJournal of Medicinal Chemistry, 1986
- Synthesis of fluorinated pyridines by the balz-schiemann reaction. An alternative route to enoxacin, a new antibacterial pyridonecarboxylic acidJournal of Heterocyclic Chemistry, 1984
- 1,4-Dihydro-4-oxopyridinecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agentJournal of Medicinal Chemistry, 1984