CD8 + T Cell Cross-Priming via Transfer of Proteasome Substrates
- 28 May 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5675) , 1318-1321
- https://doi.org/10.1126/science.1096378
Abstract
“Cross-priming” describes the activation of naïve CD8+ T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from “donor” cells. Antigen transfer is believed to be mediated by donor cell–derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses.Keywords
This publication has 21 references indexed in Scilit:
- Antigen Bias in T Cell Cross-PrimingScience, 2004
- Cellular protein is the source of cross-priming antigenin vivoProceedings of the National Academy of Sciences, 2004
- HSP70 Peptide Binding Mutants Separate Antigen Delivery from Dendritic Cell StimulationImmunity, 2004
- The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residuesNature Immunology, 2002
- Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune ResponsesAnnual Review of Immunology, 2002
- Producing Nature’s Gene-Chips: The Generation of Peptides for Display by MHC Class I MoleculesAnnual Review of Immunology, 2002
- Characterization of the ovalbumin‐specific TCR transgenic line OT‐I: MHC elements for positive and negative selectionImmunology & Cell Biology, 2000
- A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.Proceedings of the National Academy of Sciences, 1994
- The Genetic Control of HLA‐A and B Antigens in Somatic Cell Hybrids: Requirement for β2 MicroglobulinTissue Antigens, 1978
- Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.The Journal of Experimental Medicine, 1976